Proton Pump Inhibitors (PPIs) & Cognitive Impairment: Brain Not Working?

Over the past few months I’ve been taking a PPI (proton-pump inhibitor) called “Esomeprazole” (Nexium) to manage a condition called laryngopharyngeal reflux (LPR). I take the Esomeprazole (Nexium) at a dosage of 20 mg twice daily (b.i.d.). The medication is partially effective in reducing some of my most severe symptoms of LPR including: ear pain; …

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Melatonin Tolerance: No Evidence It Exists?

Melatonin is a hormone endogenously secreted by the pineal gland at night/evening and regulates one’s circadian rhythm (i.e. sleep-wake cycle) via interaction with melatonin receptors in the brain. Melatonin also: regulates blood pressure; interacts with the immune system; and acts as a potent antioxidant (scavenging free radicals). It has been thought that melatonin production decreases …

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Creatine for Brain & Cognitive Enhancement: An Underrated Nootropic?

When I first started lifting weights, the two marquee supplements being pimped out by every website, fitness YouTuber, and personal trainer at gyms included: whey protein and creatine monohydrate.  Because I ate plenty of protein and knew that creatine could be attained via my diet – I abstained from purchasing either of the aforementioned supplements.  …

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