ppis Archives - drewisdope

Proton Pump Inhibitors (PPIs) & C. Diff Infection Risk: Concerning?

June 19, 2022May 25, 2022 by Drew

Although PPIs are generally safe medications for most people, some users are concerned with increased risk of infection – particularly C. diff (Clostridium difficile). I happen to be: (A) a PPI user (esomeprazole 20 mg, b.i.d.) and (B) someone who’s concerned with potential increased risk of C. diff – so I reviewed the literature on …

PPI Stopped Working: Tolerance Onset? Ideas & Solutions

July 9, 2022February 9, 2022 by Drew

Proton-pump inhibitors (PPIs) are medications that induce profound and prolonged reduction of stomach acid production by irreversibly inhibiting the H+/K+-ATPase proton pump. These medications are utilized as monotherapy or adjunct interventions for the treatment of: gastroesophageal reflux disease (GERD) & laryngopharyngeal reflux (LPR); Barrett’s esophagus; eosinophilic esophagitis; gastritis; gastrinomas; dyspepsia; peptic ulcer; Zollinger-Ellison syndrome; and …