stopped working Archives

PPI Stopped Working: Tolerance Onset? Ideas & Solutions

July 9, 2022February 9, 2022 by Drew

Proton-pump inhibitors (PPIs) are medications that induce profound and prolonged reduction of stomach acid production by irreversibly inhibiting the H+/K+-ATPase proton pump. These medications are utilized as monotherapy or adjunct interventions for the treatment of: gastroesophageal reflux disease (GERD) & laryngopharyngeal reflux (LPR); Barrett’s esophagus; eosinophilic esophagitis; gastritis; gastrinomas; dyspepsia; peptic ulcer; Zollinger-Ellison syndrome; and …

Melatonin Stops Working: Causes & Solutions

July 1, 2022December 1, 2021 by Drew

Melatonin is an endogenous hormone produced by the pineal gland that helps regulate the circadian rhythm. At night, melatonin levels increase (100-300 ng/mL) – and this serves as a physiological signal that it’s time for sleep, and thus we become drowsy/sedated – and inevitably fall asleep. For a variety of reasons, many people decide to …