Research

PPI Stopped Working: Tolerance Onset? Ideas & Solutions

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Proton-pump inhibitors (PPIs) are medications that induce profound and prolonged reduction of stomach acid production by irreversibly inhibiting the H+/K+-ATPase proton pump. These medications are utilized as monotherapy or adjunct interventions for the treatment of: gastroesophageal reflux disease (GERD) & laryngopharyngeal reflux (LPR); Barrett’s esophagus; eosinophilic esophagitis; gastritis; gastrinomas; dyspepsia; peptic ulcer; Zollinger-Ellison syndrome; and …

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Melatonin Tolerance: No Evidence It Exists?

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Melatonin is a hormone endogenously secreted by the pineal gland at night/evening and regulates one’s circadian rhythm (i.e. sleep-wake cycle) via interaction with melatonin receptors in the brain. Melatonin also: regulates blood pressure; interacts with the immune system; and acts as a potent antioxidant (scavenging free radicals). It has been thought that melatonin production decreases …

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High Dose Melatonin: Therapeutic or Dangerous?

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What is high-dose melatonin? There’s no objective scientific/medical consensus for what is “high-dose” melatonin. You might ask several people what they consider to be a high-dose of melatonin – and you might get entirely different answers. The body endogenously produces between 100 and 300 mcg (micrograms) of melatonin per night (according to a medical doctor …

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Chronic Lyme Disease: A Fake Condition?

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“Chronic Lyme” is colloquially regarded as symptoms of Lyme disease (caused by bacterium: Borrelia burgdorferi – or other Borrelia spp.) that linger for protracted durations after both diagnosis and medically-appropriate treatment of Lyme disease. What most people think “chronic Lyme” is… Many individuals think that “chronic Lyme” is Lyme disease that is still lingering in …

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Low Dose Melatonin: Optimal for Circadian Rhythms?

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What is low dose melatonin? 300 mcg (micrograms) or less – equivalent to 0.3 mg or less. This is my answer – so let me explain how I came up with this number. There’s no objective scientific/medical consensus for what is “low-dose” melatonin. You might ask several friends what they consider to be low-dose melatonin …

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Melatonin Stops Working: Causes & Solutions

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Melatonin is an endogenous hormone produced by the pineal gland that helps regulate the circadian rhythm. At night, melatonin levels increase (100-300 ng/mL) – and this serves as a physiological signal that it’s time for sleep, and thus we become drowsy/sedated – and inevitably fall asleep. For a variety of reasons, many people decide to …

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