A subset of LPR patients may exhibit underlying abnormalities in autonomic nervous system (ANS) function and/or brain activation – which causes and/or sustains the LPR condition. Another subset of “LPR patients” may actually have a functional esophageal disorder or a somatic symptom disorder wherein either: connections in the brain are erroneous (functional) or anxiety is …
There is a considerable amount of evidence suggesting that pepsin, a common digestive enzyme, is involved in the pathogenesis/pathophysiology of laryngopharyngeal reflux (LPR) disease. (R) Specifically, it is thought that pepsin ends up refluxed into the laryngopharynx from the stomach whereafter it causes damage, inflammation, and dysfunction of the: cells, tissue, mucosal membranes, nerves, and/or …
How being overweight/obese may cause reflux… Emerenziani et al. (2020) highlighted a variety of ways in which obesity could contribute to reflux conditions (e.g. GERD) and a host of other gastrointestinal disorders. (R) Transient LES relaxation (TLESR): This is thought to be the primary mechanism by which being overweight/obese causes/exacerbates reflux. The primary stimulus for …
The reason I wrote this article is because I’ve subjectively noticed on repeated occasions, that the mere act of “talking” (i.e. speaking) significantly seems to worsen my laryngopharyngeal reflux (LPR) condition – even when stress is extremely low (relaxation is high). How “talking” could cause or exacerbate reflux (Mechanisms) Talking/speaking may significantly worsen reflux for …
Laryngopharyngeal Reflux Research Findings (2022) Brief takeaways from LPR research in 2022 are compiled below in list format. Age associated with LPR: Older age is associated with increased risk of LPR. Alginate suspension vs. PPI (omeprazole): Thrice daily administration of alginate suspension (magnesium alginate) might be as effective as omeprazole (20 mg) – when combined …