tolerance

PPI Stopped Working: Tolerance Onset? Ideas & Solutions

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Proton-pump inhibitors (PPIs) are medications that induce profound and prolonged reduction of stomach acid production by irreversibly inhibiting the H+/K+-ATPase proton pump. These medications are utilized as monotherapy or adjunct interventions for the treatment of: gastroesophageal reflux disease (GERD) & laryngopharyngeal reflux (LPR); Barrett’s esophagus; eosinophilic esophagitis; gastritis; gastrinomas; dyspepsia; peptic ulcer; Zollinger-Ellison syndrome; and …

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Melatonin Tolerance: No Evidence It Exists?

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Melatonin is a hormone endogenously secreted by the pineal gland at night/evening and regulates one’s circadian rhythm (i.e. sleep-wake cycle) via interaction with melatonin receptors in the brain. Melatonin also: regulates blood pressure; interacts with the immune system; and acts as a potent antioxidant (scavenging free radicals). It has been thought that melatonin production decreases …

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Melatonin Stops Working: Causes & Solutions

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Melatonin is an endogenous hormone produced by the pineal gland that helps regulate the circadian rhythm. At night, melatonin levels increase (100-300 ng/mL) – and this serves as a physiological signal that it’s time for sleep, and thus we become drowsy/sedated – and inevitably fall asleep. For a variety of reasons, many people decide to …

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