PPI Stopped Working: Tolerance Onset? Ideas & Solutions

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Proton-pump inhibitors (PPIs) are medications that induce profound and prolonged reduction of stomach acid production by irreversibly inhibiting the H+/K+-ATPase proton pump. These medications are utilized as monotherapy or adjunct interventions for the treatment of: gastroesophageal reflux disease (GERD) & laryngopharyngeal reflux (LPR); Barrett’s esophagus; eosinophilic esophagitis; gastritis; gastrinomas; dyspepsia; peptic ulcer; Zollinger-Ellison syndrome; and …

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PPI Worsening Reflux: Why Does This Happen?

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On various websites and forums, there are reports of PPIs (proton-pump inhibitors) causing worse reflux than before using them (i.e. pre-PPI baseline). Additionally, many alternative health practitioners (e.g. naturopaths, chiropractors, etc.) promote the idea that PPIs always worsen reflux – and many people legitimately believe this to be accurate. The truth is that while a …

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MAC Lung & Humidifiers

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Many people with MAC lung infection (NTM) wonder whether it’s okay to use a “humidifier” with the condition. Depending on who you ask, you may get vastly different responses. Some think using a humidifier is perfectly fine – as long as certain precautions are taken whereas others think it’s too risky. Humidifiers can cause MAC …

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War On Drugs: Winners (Singapore) & Losers (U.S.A.)

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Why did the “War on Drugs” fail massively in the United States? In my opinion, the “War on Drugs” massively failed in the U.S. because the U.S. was never serious about winning it. If the U.S. were serious about actually winning a war on drugs, it would: Invest money and resources in drug use/abuse prevention …

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Melatonin Tolerance: No Evidence It Exists?

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Melatonin is a hormone endogenously secreted by the pineal gland at night/evening and regulates one’s circadian rhythm (i.e. sleep-wake cycle) via interaction with melatonin receptors in the brain. Melatonin also: regulates blood pressure; interacts with the immune system; and acts as a potent antioxidant (scavenging free radicals). It has been thought that melatonin production decreases …

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High Dose Melatonin: Therapeutic or Dangerous?

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What is high-dose melatonin? There’s no objective scientific/medical consensus for what is “high-dose” melatonin. You might ask several people what they consider to be a high-dose of melatonin – and you might get entirely different answers. The body endogenously produces between 100 and 300 mcg (micrograms) of melatonin per night (according to a medical doctor …

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