Diphenhydramine is a first-generation ethanolamine antihistamine developed by George Rieveschl and was approved for usage in 1946. In the U.S. and Canada – diphenhydramine is the primary active ingredient in the over-the-counter medication “Benadryl.” As of 2017, diphenhydramine was the 241st most commonly prescribed medication in the U.S. – exceeding 2M prescriptions. Total usage of …
Tuberculosis is an infectious disease caused by the pathogen “Mycobacterium tuberculosis” – a bacterium with a waxy coating on its cellular surface due to the presence of mycolic acid. Although tuberculosis is often successfully treated with antibiotics and sometimes prevented with the BCG vaccine – there are many cases of TB that: (A) are not …
I first read about “turkesterone” on Reddit and initially thought it was a fictitious substance that: someone made up to be funny and/or was part of an inside joke. Like bro have you tried turkesterone? Gains are legit better than steroids. However, I later observed several influencers with large followings namedrop “turkesterone” and realized it …
Anxiety medications (i.e. anxiolytics) are drugs that prove safe, tolerable, and effective in clinical trials for the treatment of “anxiety” or chronic stress. Many people derive either: (A) significant or (B) partial – therapeutic benefit from currently-available anxiolytic agents such that they help manage/reduce anxiety symptoms. However, many individuals find that currently-available anxiolytics are problematic …
Antidepressants: (1) They help some, (2) they don’t do much for others (maybe cause emotional blunting/numbness), and (3) they worsen preexisting depression and/or cause new-onset symptoms such as anxiety for another subset of users. The treatment of depression is essentially one big neurochemical crapshoot (i.e. gamble) that involves trial and error. Give people meds that …
On June 4, 2021, the FDA approved a new weight loss drug called Wegovy (Semaglutide). That said, technically the drug is not new – it was initially approved in 2017 under the brand name Ozempic as an adjunct treatment for type 2 diabetes. Wegovy (Semaglutide) is administered by injection (2.4 mg) once per week for …