DREW IS DOPE

Drugs

Brain

Melatonin Tolerance: No Evidence It Exists?

Melatonin is a hormone endogenously secreted by the pineal gland at night/evening and regulates one’s circadian rhythm (i.e. sleep-wake cycle) via interaction with melatonin receptors in the brain. Melatonin also: regulates blood pressure; interacts with the i…

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Drugs

High Dose Melatonin: Therapeutic or Dangerous?

What is high-dose melatonin? There’s no objective scientific/medical consensus for what is “high-dose” melatonin. You might ask several people what they consider to be a high-dose of melatonin – and you might get entirely different answers. The body endogenous…

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Drugs

Low Dose Melatonin: Optimal for Circadian Rhythms?

What is low dose melatonin? 300 mcg (micrograms) or less – equivalent to 0.3 mg or less. This is my answer – so let me explain how I came up with this number. There’s no objective scientific/medical consensus for what is “low-dose” melatonin. You might ask sev…

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Drugs

Melatonin Stops Working: Causes & Solutions

Melatonin is an endogenous hormone produced by the pineal gland that helps regulate the circadian rhythm. At night, melatonin levels increase (100-300 ng/mL) – and this serves as a physiological signal that it’s time for sleep, and thus we become drowsy/sedate…

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Drugs

Caffeine & OCD: Exacerbator or Treatment?

What effect does caffeine have on OCD? It likely depends on the specific person with OCD. Not everyone with OCD or a predisposition to OCD will respond identically to caffeine. This is because individuals differ in gene expression, brain morphology, neurochemi…

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